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The Role of Vitamins and Supplements When Using Weight Loss Medication

  • July 7, 2025
  • Lifestyle Med Spa
Now that over 6% of US adults have dabbled with weight loss medications (over 20 million people!), it’s becoming more evident that supplements play an important role in healthy weight loss. After all, medications are imperfect weight management tools with their own unique side effects and downsides. Making the most of your weight loss journey requires knowing exactly what your body needs to thrive.

To promote weight loss more effectively, while taking in all the essential nutrients your body relies on, consider introducing weight loss supplements to your treatment plan. Not sure where to start? Lifestyle Med Spa’s licensed physicians and dieticians have outlined the most effective supplements, backed by reliable clinical trials. Read on to find the best supplement for your situation.

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Weight Loss Supplements

What Are Weight Loss Supplements?

The term “weight loss supplements” refers to a broad collection of probiotic, vitamin and mineral supplements that help people lose weight naturally. Similar to weight loss medications like Ozempic, these natural supplements improve GLP-1 hormone balance and other crucial bodily chemicals that impact your metabolic health.

Why Dietary Supplements Are Crucial For Your Medical Weight Loss Journey

When you start using GLP-1 or GLP-1/GIP prescription medications to shed excess weight, your body goes through several major changes. From appetite and digestion to energy production and nutrient absorption, essential vitamins and other supplements can help you increase fat breakdown and build permanent healthy habits.
Here are some of the many reasons you should start taking supplements:
  • Reduced appetite: When weight loss medications cause you to consume fewer calories and micronutrients, you need supplements to help bridge nutritional gaps.
  • Digestive changes: GLP-1 and GLP-1/GIP medications are known to slow gastric emptying, which can reduce absorption of fat-soluble vitamins. Low vitamin D levels are especially common and can be remedied with various supplements.
  • Increased metabolic demand: Consistently losing body fat puts higher demand on your metabolism, but supplements support better energy production, hormone balance, and muscle function.
  • Immune system support: Reducing caloric intake can impact immune function, but supplements can help you get all the essential nutrients you need to maintain strong defenses.
  • Hair, skin, and nail health: Rapid weight loss can cause nutrient deficiencies that impact skin elasticity, hair strength, and nail growth. Luckily, supplements provide complementary and integrative health benefits, like the building blocks for healthy skin, hair, and nails.
  • Higher energy expenditure: Targeted vitamins and minerals support energy production throughout your medical weight loss journey.
The Best Vitamins and Supplements For Weight Loss
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The Best Vitamins and Supplements For Weight Loss

While there are countless dietary supplements you could consider adding to your weight management plan, we’ve gathered a list of some of the best, evidence-based options. Consider discussing them with your healthcare provider to see how they might impact your current prescriptions and health conditions.

Apple Cider Vinegar (ACV)

Apple cider vinegar is a probiotic-rich concoction that’s been around since ancient times. Today, it can be taken as a supplemental way to support appetite control, blood sugar balance, and improved digestion. It’s especially effective when paired with GLP-1 medications, as it boosts the medication’s ability to regulate glucose spikes and feelings of fullness.
We recommend using ACV daily, either as a drink diluted in water or blended with food intake.

Yerba Mate Tea

Unlike green tea extract, which has shown mixed results in clinical trials, yerba mate tea has ferulic acid compounds capable of boosting GLP-1 levels by 40–50%. This allows the tea to work synergistically with GLP-1 medications to promote calorie control without leaving you feeling sluggish. Plus, the beverage is also rich in antioxidants, increasing fat oxidation—the process of breaking down fat for energy.
By drinking at least one cup per day (3g of tea leaves) for up to 12 weeks, you can reduce inflammation and fat buildup.

Omega-3 Fatty Acids

Improve your eating habits by swapping processed fats for omega-3-rich sources like fish oil, flaxseed, or algae-based supplements. These essential fats that the body can’t produce naturally reduce inflammation, support heart health, and improve insulin sensitivity. They also help preserve lean muscle mass during weight loss, giving you a healthier and more sustainable figure.
Most suggest taking at least 2g per day, but we ultimately recommend reaching out to a healthcare provider for more personalized dosing.

Collagen Peptides

While not commonly cited as a weight loss supplement, collagen peptides offer several benefits for patients using medication. They’re typically used for skin treatments, but can also help people losing weight maintain healthy joints, lean muscle, and skin elasticity. Some studies even show an impact on the GLP-1 response, suggesting that those taking collagen peptides can burn fat faster while maintaining firm skin and strong muscles.
Talk to your doctor about how you can best incorporate collagen peptides into your daily routine.

Probiotics and Synbiotics

Though ACV touches on the importance of probiotics, helpful microorganisms that improve fat absorption and other aspects of digestion, there are many delivery methods. From fermented foods to powders and synbiotic capsules (probiotics + prebiotics), this supplement helps restore balance in the gut microbiome, especially for those on GLP-1 or GLP-1/GIP medications. In turn, a healthier gut can better regulate appetite and metabolism.
Talk to your doctor about which type of probiotic is right for you, as well as how much you should take daily.

Individual Vitamins and Multivitamins

There are a variety of vitamins you can use to prevent deficiencies and supplement your weight loss journey, all of which having their own benefits. Here’s how a few specific vitamins make a difference:
  • Vitamin D: When GLP-1 medications negatively impact vitamin D levels, taking vitamin D supplements can support bone strength, immune function, and mental health. 1000 units daily is a typical dosage, but always adhere to your doctor’s recommendations.
  • Vitamin B12: Low B vitamins, such as B12, are another common issue that can cause fatigue and weakness, especially when you’re consuming fewer calories. Taking 1,000 mcg of B12 daily or weekly, depending on your blood work, can improve nerve health and metabolism function.
  • Vitamin C: As your body weight decreases rapidly, loose or sagging skin can start to become an issue. Luckily, vitamin C supports the collagen production, immune defense, and antioxidant protection your body needs to repair tissue.
  • Multivitamin Blends: Not sure which vitamins you need to improve your weight loss journey? Physician-approved multivitamins fill multiple nutrient gaps at once, especially when daily calorie intake is consistently low.

Magnesium, Iron, and Other Minerals

Similar to vitamins, your body also relies on essential minerals for a healthy metabolism, blood pressure, muscle function, and more. GLP-1 and GLP-1/GIP medications can sometimes interfere with absorption, making these additions even more important:
  • Magnesium: A vital mineral that supports over 300 biochemical reactions, including muscle and blood vessel relaxation to reduce high blood pressure and painful muscle contractions. Taking 200–400 mg daily, depending on your doctor’s recommendation, can help you stay healthy while you lose weight.
  • Iron: Crucial for maintaining energy and preventing anemia, you can take 18–27 mg of iron daily (depending on blood work) with vitamin C for better absorption.
  • Calcium: Rapid weight loss can put stress on your bones, but taking 1,000–1,200 mg per day (depending on your age), can help maintain healthy bone density.
  • Zinc: For an improved metabolic rate and tissue healing while on weight loss medication, consider adding 8–11 mg of zinc to your daily routine. Many multivitamins also include this mineral.
  • Selenium: A trace mineral that boosts thyroid health and antioxidant activity, helping regulate metabolism and protect cells during fat breakdown. Just 240 mcg per day has been shown to help people lose weight more effectively.
Tips For Pairing Weight Loss Medications and Dietary Supplements Wisely
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Tips For Pairing Weight Loss Medications and Dietary Supplements Wisely

To get the most out of your weight loss supplements, you’ll need to consume them safely and properly. Here are some of our tips for effective use:

1. Blood Work First

Before you start taking any supplement, especially vitamins and minerals like B12, iron, or magnesium, always request routine blood work from your healthcare provider. This will let you know where you need to fill gaps and help prevent overdose.

2. Take Vitamins With Meals

Your body has an easier time absorbing fat soluble vitamins like A, D, E, and K when you take them with a little bit of dietary fat. This includes foods like avocados, nuts, salmon, and seeds.

3. Have a Supplement Schedule

Having a dedicated schedule for your supplements can help you remember to take them consistently, and take them when they’ll be most effective. For example, magnesium and B vitamins have a calming effect that works well for evenings, while iron and calcium should be taken separately because they compete for absorption. Try putting reminders on your phone or keeping a helpful calendar within view.

4. Stay Hydrated

Staying hydrated with low-sugar beverages supports digestion, reducing the risk of constipation and slowed gut motility. Water is generally the best option, but you can also get hydration from kombucha, tea, and even soups.

Achieve a Sustainable Weight Loss With Lifestyle Med Spa!

Vitamins and other supplements are a great way to stay healthy and boost your progress while on weight loss medication, but it’s important to take them under professional guidance. At Lifestyle Med Spa, we combine the latest injectable weight loss medications with expert dietary advice and natural remedies for the most effective weight management plans.

Plus, we offer a variety of other treatments as well. Whether you need help with chronic fatigue or sagging skin, we’re committed to helping you achieve the best results. Click here to start your free consultation.

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