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What Are GLP-1 Weight Loss Drugs, and How Do They Work?

Glucagon-like peptide-1 (GLP-1) receptor agonists mimic a naturally-occurring group of bodily hormones that aid in glycemic control, digestion, and appetite. As an injectable medication, it accomplishes this by stimulating the pancreas to release more insulin, slowing down the stomach emptying process, and reducing feelings of hunger. The result: lower blood sugar levels and more progress toward your weight loss journey.
When deciding whether GLP-1 injection is right for you, it’s important to consider different brand names and their effects, as well as your family history. We’ll work with your healthcare provider to help determine the best option based on half-life, effectiveness, side effects, and affordability.
GLP-1 Vs. GLP-1/GIP Medications
The primary difference between GLP-1 agonists and GLP-1/GIP dual agonists is the ability to target more than one metabolic pathway. This ability generally makes GLP-1/GIP options more effective for weight loss and blood sugar control, but GLP-1 options also offer well-established research with fewer gastrointestinal side effects.
GLP-1 Medications
  • How it works: GLP-1 Agonist that only targets the GLP-1 receptor, without the added effects of GIP receptor activation.
  • Results: Studies show patients losing an average of around 14.9% of their body weight in clinical trials.
  • Brand Names: Available as Ozempic and Wegovy.
GLP-1/GIP Medications
  • How it works: Dual Agonist that activates both GIP and GLP-1 receptors.
  • Results: In studies, patients experienced a 15-22% reduction in body weight, exceeding what is typically seen with GLP-1 agonists alone.
  • Brand Names: Available as Mounjaro and Zepbound.
During our initial consultation, we will conduct a comprehensive medical review and decide the best medicine for you.

Are GLP-1 Medications FDA approved?

YES – GLP-1s are FDA approved for treating type 2 diabetes. Certain injections are also approved for chronic kidney disease (CKD) treatment.
Another brand name GLP-1 drug called Wegovy was approved specifically for weight loss in 2021 based on evidence from four 68-week trials involving 4,500 patients. These trials consistently showed that those taking the injection experienced substantial weight loss.

GLP-1 Clinical Trial Weight Loss Results

  • Participants: Over 1,900 adults with obesity or overweight.
  • Results: Participants taking GLP-1 injections lost an average of 14.9% of their body weight over 68 weeks, compared to 2.4% for those taking a placebo

Potential Side Effects of GLP-1 Injectables

While GLP-1 injections are approved by both the FDA and the American Diabetes Association, it’s important to understand the most common side effects before you start treatment. GLP-1 injections can all cause mild to moderate side effects that often improve over time. Serious allergic reactions are rare but possible.
Prior to starting treatment, Dr. Michael Rankin will review your medical history to ensure the safest and most effective approach for your weight management plan. Please let us know about any history of diabetes, acute kidney injury, cancer, or any other serious or chronic health conditions.
Common Side Effects:
  • Redness or bruising around the injection site
  • Nausea
  • Vomiting
  • Diarrhea
  • Abdominal pain
  • Constipation
Mitigating Side Effects and Osteoporosis Risk
To mitigate potential side effects, including the possibility of decreased bone mineral density as the result of significant weight loss, we recommend:
  • Starting with a Lower Dose: Starting treatment at a lower dose and gradually increasing it can help your body adjust.
  • Dietary Changes: Eating smaller, more frequent meals and avoiding high-fat or spicy foods can help reduce gastrointestinal discomfort.​
  • Hydration: Staying hydrated during your treatment is essential, especially if you’ve experienced any vomiting or diarrhea.​
  • Daily Exercise: Even if you’re not interested in strength training, consistent activity like walking, jogging, or swimming can reinforce bones and counteract bone density loss.

Why Choose Lifestyle for Your Weight Loss Journey

At Lifestyle Med Spa, we take weight reduction, cardiovascular health, and diabetes treatment seriously. Our licensed medical professionals provide comprehensive, personalized injectable treatments that go beyond the spa, providing you with the ongoing support and wellness services you need to reach your goals.
1
Expert Medical Care
Our qualified physicians and nurses conduct thorough medical evaluations that analyze the rate of weight loss, glucose production, and more. This ensures the safety and effectiveness of your treatments. We even offer 24/7 emergency support if you require immediate medical attention.
2
Convenient & Personalized Service
Weight loss is an extremely personal journey, and we’re here for you every step of the way. Whether you need specialized diet advice, answers to questions, or additional guidance, our team is dedicated to your success. We’re always on-time, eager, and ready to help, making your visits smooth and stress-free.
3
Added Health & Wellness Benefits
Our services go beyond weight loss. Enjoy our complimentary B12 skinny injections to boost energy and metabolism, or look into our other wellness services. We can help with anything from Vitamin IV Drips to Personal Training.
4
Advanced Body Composition Analysis
We include an Evolt 360 Body Composition Scan, which provides detailed data about your body through more than 40 measurements. The sophisticated analysis of your body mass and other vital indexes ensures healthy weight loss, and preservation of lean muscle.
5
Lifestyle Changes for Lasting Results
In addition to GLP-1 treatments, we carefully review your diet and exercise habits to help you maintain your results and prevent future weight gain. Learn how to incorporate simple, enjoyable lifestyle changes and natural remedies that accelerate weight loss and improve long-term health.

Meet Our Team

Micheal

Michael Rankin, MD, Medical Director

Michael B. Rankin, MD is a diplomate of the American Board of Internal Medicine

CHIC2420

Kristina, Family Nurse Practitioner

Kristina is a board-certified Family Nurse Practitioner and earned her Master of Science in Nursing from West Coast University in 2023. She has been a registered nurse since 2016 with a diverse background in the operating room and aesthetics/integrative medicine. Kristina specializes in treatments including intravenous infusions, vitamin therapy, PRP injections, and hydrafacials. She has a passion for helping people lead healthier lives and her interests are rooted in preventive care and believes in a whole-person approach to medical care. In her free time, Kristina enjoys being active and can be found in her off days hiking, exercising in many forms, and spending time with family and friends. See More 

Kim-B

Kim B. Barrus Ph.D., Chief Of Operations

Kim B. Barrus, Ph.D. is chief of operations, and the founder of Lifestyle Health Care Services

Anjmun Sharma, MD

Anjmun Sharma, MD

Dr. Anjmun Sharma, MD, is a highly skilled and certified physician specializing in occupational medicine. He is an Aviation Medical Examiner (A.M.E.) and a Designated Civil Surgeon for USCIS. Dr. Sharma is Level II Certified by the Division of Workers' Compensation (DOWC) in Colorado and holds MRO certification. He also serves as an Independent Medical Examiner for the State of Colorado’s Department of Labor & Employment, Division of Workers' Compensation. Dr. Sharma practices at Monument Occupational Medicine, PC, in Colorado Springs, where he provides comprehensive medical services tailored to the needs of his patients. See More 

Traci

Traci Babcock, RN, NP

Traci Babcock RN NP is an experienced board-certified nurse practitioner with Family Psychological Services

Jaime

Jaime Raymond, Plasma Fibroblast Pen Technician

Has been in the beauty industry for 16 years as a makeup/hair artist and have worked with multiple celebrities. Is currently certified as a Plasma Fibroblast pen technician

Giselle Morales

Giselle Morales, Medical Assistant

Giselle’s background includes 4 years of dedicated esthetic practice and 5 years of experience as a medical assistant. Her expertise in a range of beauty treatments and a deep understanding of the latest advancements in skin health allows her to be dedicated to helping individuals achieve their unique wellness goals and allows her to approach each client with a comprehensive understanding of their needs. From personalized skin care regimens to innovative treatments like weight loss injections and nutritional booster therapies, she is committed to empowering clients with the knowledge and tools necessary to unlock their full potential. See More 

Lifestyle Health Services

Nicole Caunan, Medical Assistant

Lifestyle Med Spa - Our Story

Dr. Kim Barrus, our chief of operations, took Ozempic/Wegovy and lost 22 pounds in four months. He felt more energetic, confident, and healthier.
As he dived into the research, it supported his own experience that these medicines are powerful for looking and feeling better and improving health.
He opened the medical spa to provide these treatments, whether for obesity management or high blood pressure, to his clients from Ventura and Los Angeles counties and throughout Southern California.
As the medical spa has grown, we offer other services to support your health and wellness.

Success Stories

Jaime took GLP-1 Injections and lost 47 lbs in 5 months.

When To Consider Natural Remedies For Weight Loss

Natural remedies may not be as fast or effective as GLP-1/GIP injectables, but whether deployed separately or in tandem with weight loss medications, they can help you make progress toward your goals. Some of the most effective natural remedies with can help with include:
  • Yerba Mate Tea: Effective for boosting metabolism and fat oxidation, this tea helps increase energy levels and reduce cravings.
  • Allulose Sweetener: This tasty low-calorie sugar alternative doesn’t spike blood sugar, supporting metabolic health and reducing symptoms of type 2 diabetes.
  • Optimizing Sleep: Prioritizing a restorative 7–9 hours sleep aids in regulating hormones and controlling appetite, both crucial elements of weight loss.
  • Nutritional Guidance (Keto Diet): A low-carb (20g or less per day), high-protein, and high-fat diet helps to promote ketosis, a process of efficient fat burning and stable blood-sugar levels.
  • Collagen Peptides: These proteins support muscle maintenance during weight loss, as well as post-weight loss skin elasticity and joint health.
  • Apple Cider Vinegar: A fantastic natural remedy for improving digestion and reducing appetite, this vinegar helps regulate blood sugar.

GLP-1s: Frequently Asked Questions

GLP-1 is a naturally occurring hormone in the body that regulates blood sugar and appetite. GLP-1 agonists are a class of medications that mimic the effects of weight management, reducing appetite and promoting weight loss.
Yes, GLP-1 medications are generally safe and well-tolerated. However, like any medication, there may be potential side effects, and it’s important to discuss the risks and benefits with your healthcare provider.
GLP-1 medications are FDA-approved to treat type 2 diabetes, obesity, and even chronic kidney disease (CKD), depending on the brand. You should be a good candidate for treatment if you have any of these concerns, so long as you don’t have any allergies or conditions that would cause a conflict. We’ll discuss potential conflicts further during your initial consultation.
Results can vary, but most individuals see some weight loss within the first few weeks of starting GLP-1 therapy. The full effects may take several months to achieve.
A balanced diet (healthy fats, protein, fiber, etc.) and regular exercise are important components of any weight management plan. Your healthcare provider may also recommend additional lifestyle changes or other medications to support weight loss.
No, you do not need to come into our office at all. Our doctor can do a remote consultation with you and mail the medicines to you. They are simple to inject yourself. We do follow-up consultations via phone. If your schedule allows, we recommend doing the injections in the clinic because we can accelerate your weight loss based on your tolerance to the medication.

Service Areas

We are based in Agoura Hills, CA, and proudly serve clients in the surrounding areas. Additionally, we offer remote consultations for medical weight loss and are happy to ship injections directly to you. No matter where you are, we’re here to help you achieve your health goals.
Agoura Hills

Agoura Hills

Westlake Village

Westlake Village

Calabasas

Calabasas

Thousand Oaks

Thousand Oaks

Simi Valley

Simi Valley

Encino

Encino

Sherman Oaks

Sherman Oaks

Oxnard

Oxnard

Camarillo

Camarillo

Malibu

Malibu

Ventura

Ventura

Santa Barbara

Santa Barbara

Santa Paula

Santa Paula

Northridge Location

Northridge

West Hills

West Hills

Santa Clarita

Santa Clarita

Los Angeles

Los Angeles

Glendale

Glendale

Burbank

Burbank

Pasadena

Pasadena

Chatsworth

Chatsworth

Tarzana

Tarzana

Studio City

Studio City

Canoga Park

Canoga Park

Moorpark Location

Moorpark

Newbury Park

Newbury Park

Port Hueneme

Port Hueneme

Ojai

Ojai

Woodland Hills

Woodland Hills

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